D'OXYVA® (deoxyhemoglobin vasodilator)

Affordable, Fast, Non-invasive, Handheld, Transdermal Regenerative Circulatory Technology & Solution


Take it from the experts—D'OXYVA's solution makes a profound difference.

Without electricity, D'OXYVA's proprietary medical gas injection and mixing method delivers a gentle vapor of Supersaturated Medical CO2 + H2O Vapor™ on the skin surface to allow the CO2 to dissolve in a pure molecular form.

CO2 is a non-toxic, natural vasodilator that among other functions is responsible for auto-regulation of local blood supply throughout the body and blood pH balance. It is a signaling molecule that influences the autonomic nervous system (ANS).

According to human clinical trials with advanced FDA-cleared diagnostics, D'OXYVA achieved homeostasis between parasympathetic and sympathetic nerve activities, while improving sustained blood circulation, nutrient delivery, and waste removal for hours after each delivery.

This influences the specific areas of the macro-, and microcirculatory system in demand. In return, according to widely accepted experimental and clinical research, the ANS influences several major physiological processes.

D'OXYVA has consistently recorded boosting athletic performance for people at any age, improving skin health, sleeping, appetite, mood, and mental health. D'OXYVA has significantly reduced the risks of serious complications for cardiovascular, diabetic and cancer patients.

  • Powerful, affordable and convenient application requiring no special training

  • Non-invasive operation without stains allowing high dosage and application flexibility

  • The fastest handheld applications on the market entirely free of pain and adverse side effects

  • Operates simply on water without needles, electricity, and equipment failure

  • Dissolves in the skin easily without electrical or mechanical disruption and skin irritation

  • Affordable state-of-the-art patented technology with zero waste and zero adverse event reports

> Visit www.doxyva.com to purchase and learn more


Circularity's patented and patent-pending technology for D'OXYVA is based on our company's novel method of controlling carbon dioxide (CO2) flow when combined with water under specific pressure.

A flow regulator, at the heart of the control mechanism, has been precisely designed and tuned to maximize the CO2 gas reliability when injected from the cartridge containing liquid CO2 under pressure into the water capsule where the Supersaturated CO2 + H2O Vapor™ is created.

Published independent clinical research describes that it would not be possible to generate such physiological effects; improved blood flow shunting, molecular oxygenation levels, nutrient delivery, waste removal, and efficient transdermal delivery without the high CO2 content in D'OXYVA's supersaturated CO2 vapor.

If you are a health professional and would like more information on the Circularity process, contact us to receive clinical papers and read our References.


Medical gas research took a giant step forward in 1998 when Robert Furchgott, Louis Ignarro, and Ferid Murad were awarded the 1998 Nobel Prize in Medicine for their discoveries concerning the role of gaseous nitric oxide (NO) as a signaling molecule in the cardiovascular system.

Among other things, their work created an understanding of how modulating the levels of nitric oxide gas in the blood vessels can be used to benefit cardiovascular health, sexual function, athletic performance, and more.

The mechanism of action of the blockbuster drug Viagra® can be traced directly to the breakthroughs in nitric oxide gas research. CO2 has similar, but more powerful characteristics to NO with faster and easier delivery into the body.

Clinical Evidence

Based on human clinical trials that recorded the underlying mechanism of action of boosted cellular oxygen-rich microcirculatory blood flow, D'OXYVA is thought to rapidly and lastingly induce the well-known oxygen curve shift (Bohr effect) while improving autonomic nervous system and microvascular functionality. This has demonstrated the generation of auto-regulation of local blood supply, efficient nutrient delivery, and waste removal where the body has the highest demand.


In spite of the huge technological punch it packs, the D'OXYVA device is quite small and easy to handle without the need for electricity.

Made of leading-edge composite materials, its tiny footprint is just 15" long, 1½ inches diameter and weighs less than a pound. Health has never been so convenient.

The device is equipped with a 5-year limited warranty. If at any time the device proves defective or stops functioning properly as a result of intended use, Circularity will replace the device at no cost with proof of purchase during the warranty period.

For full instructions, please read Circularity Warranty Statement and Certificate included with device packaging.

Important Information

Circularity's D'OXYVA is not indicated for use in people with very high (>190/90 mmHg) or low (<80/50 mmHg) blood pressure, pregnant women, orally, or directly on unhealthy skin surfaces. Avoid inhaling carbon dioxide directly as it may cause temporary shortness of breath and cause injury!

D'OXYVA has not been evaluated yet by the U.S. Food and Drug Administration (FDA) and is not intended to diagnose, treat, cure, or prevent any disease. The information provided on this Website is not intended to replace medical advice. Ask your therapist or physician about using D'OXYVA. Results may vary by individual. Read our regulatory statements by clicking here.